Yes, while this new version of the Monarch Spin DNA Gel Extraction Kit (NEB #T1120) is developed with performance improvements, the kit buffers from the previous version are compatible. Using the kit with other Monarch buffers from previous versions will still generate high-quality, purified DNA suitable for various downstream applications. However, there may be up to 20% variance in yield in some cases when not using the supplied, matching buffers within a kit.