Performing a purification process in high salt (≥200 mM NaCl) allows impurities (nucleic acids) to detach from proteins or viruses by disrupting electrostatic interactions between these molecules. High salt can also improve protein solubility when aggregation is due to electrostatic interactions. For these reasons, many bioprocessing methods call for high salt. NEBExpress® Salt Active Nuclease can be used directly in these conditions to further alleviate high viscosity challenges, reduce back pressure, and/or remove nucleic acid.