NEBExpress Salt Active Nuclease degrades DNA and RNA, while DNase I-XT degrades DNA only. It is active between 0 and 1000 mM salt concentration (optimal at 500 mM), while DNase-I XT has been engineered to be active between 0 and 300 mM salt.  Furthermore, NEBExpress Salt Active Nuclease can be removed easily in a single column as it binds very efficiently to cation exchange resin.