N-Glycopeptide Binding Protein has been engineered to bind N-glycosylated peptides and proteins with a broad variety of N-glycoforms, including high mannose, complex, and hybrid, as well as fucosylated and non-fucosylated, sialylated and non-sialylated, with bi-, tri- and tetra-antennary structures. It also binds to non-mature glycoforms such as paucimannose and those with mannose-6-phosphate. It does not, however, bind N-glycans with bisecting GlcNAc.