IdeZ Protease efficiently cleaves human, humanized, chimeric, sheep, rabbit and monkey IgGs and also cleaves mouse IgG2a and IgG3 with an extended incubation time. IdeZ Protease will also cleave many Fc-fusion proteins as well as antibody drug conjugates (ADCs). IdeZ Protease does not cleave goat, bovine, porcine or rat IgG. It also will not cleave mouse IgG1 or IgG2b.